Every cell needs to divide and produce more cells. This is an essential part of every living organism. The first step is to make a copy of its own DNA to pass on to daughter cells. This is known as DNA replication and has been the focus of Professor Michael O’Donnell’s lab for many years. The team, based at The Rockefeller University, New York, USA has produced many firsts in the field, from identifying the unknown function of proteins to unveiling new mechanisms.